The administration of the interview was completed face-to-face with the assistance of a laptop computer. The interviewers obtained verbal informed consent from each respondent. The consent procedures no were approved by the Human Subject Research Committees at Harvard Medical School and the University of Michigan. Respondents received $50 as a token of appreciation for completing the interview. The overall response rate was 70.9%. Part I was weighted to adjust for discrepancies between the sample and the U.S. Census in terms of geographic and sociodemographic variables. Additional weighting of Part II was conducted to adjust for differential probability of selection from Part I (Kessler et al., 2004). Measures Demographics The interview included an extensive demographic section that assessed sex, age, education, marital status, and current household income.

Diagnostic assessment Lifetime and 12-month PD with or without agoraphobia, SAD, GAD, PTSD, major depressive episode, and alcohol and drug use disorders were assessed using the World Mental Health Survey Initiative version of the World Health Organization Composite International Diagnostic Interview (WMH-CIDI; Kessler & Ustun, 2004). This is a structured diagnostic interview from which DSM-IV Axis I (American Psychiatric Association, 1994) diagnoses are derived. The Composite International Diagnostic Interview has been found to have good validity and reliability for anxiety, mood, and substance use disorders (First, Spitzer, Gibbon, & Williams, 2002). Smoking history assessment Respondents completed an extensive assessment related to past and current smoking behavior.

The variables of interest were lifetime and 12-month history of daily smoking, lifetime/12-month nicotine dependence, lifetime/12-month heavy smoking, and lifetime history of failed quit attempt. Lifetime history of daily smoking was determined according to whether respondents indicated that they ever ��smoked tobacco every day or nearly every day for a period of at least 2 months.�� Twelve-month daily smoking status was determined according to whether respondents reported smoking on at least 300 days during the past 12 months (0 = no, 1 = yes). Heavy smoking status was determined according to whether respondents reported smoking 20 or more cigarettes on a typical day during the past 12 months (0 = no, 1 = yes) or during the year(s) in their lives in which they smoked most (0 = no, 1 = yes, for lifetime status).

Lifetime and 12-month DSM-IV nicotine dependence (0 = no, 1 = yes) was assessed using the WMH-CIDI (see above). In addition, lifetime history of failed quit attempts was coded according to whether respondents (a) reported making Dacomitinib two or more ��serious attempt(s) to quit smoking�� (for those who do not currently smoke) or (b) reported a past attempt but currently smoke (0 = no, 1 = yes).