Parsa, Nader Dbouk Liver transplantation

is now accepted as the treatment of choice for end stage liver failure. Pre-operative renal failure has been associated with increased post-operative morbidity and mortality and reduced graft survival at 2 years. Our own data has shown that high Imatinib clinical trial pre-operative creatinine levels are associated with a poorer overall survival at 3 months, 1, 5 and 10 years. Renal function can improve or deteriorate following orthotopic liver transplantation and our aim was to analyse changes in renal function in the immediate post-operative period on long-term graft survival following successful OLT in a large single centre prospectively collected database. Methods Data was reviewed for 1272 patients undergoing liver transplantation between 1988 and 2012. Clinical outcome was reviewed and the creatinine levels pre-operatively and at day 30 post opera-tively Afatinib solubility dmso were

documented. A ratio was calculated. Patients were placed in to 3 groups depending on their ratio. 1: patients whose renal function improved postoperatively (<1) 2: patients whose renal function was stable post-operatively (1-2) 3: patients who suffered significant deterioration post-operatively (>2). Graft survival was calculated for death from any cause and liver failure requiring re-transplantation at 3 months, 1,5 and 10 years. Results were corrected for age, cold ischaemic time, pre-operative creatinine and post-operative aspartate transaminase (both log transformed) and a full cox proportional hazard model was performed. A survival regression curve was also calculated. Results 1272 patients were identified (640M/628F/4 Unspecified). 514 records were excluded due to missing creatinine level at day 30. The mean age at time of transplantation was 47 years (Range 37-69). Improving renal function in the post-operative period correlated with improved survival at all time points (p<0.001) when compared with patients whose renal function was stable. Similarly deteriorating

renal function in the post-operative period correlated strongly with deceased survival at all time points (p<0.001) when compared with patients whose renal function was stable. Conclusions This retrospective review from a large single 上海皓元医药股份有限公司 centre prospective database has shown that post-operative changes in renal function correlate significantly with long term overall graft outcome. Changes in post-operative renal function would be an adequate outcome measure of trials aimed at improving survival following liver transplantation. Disclosures: The following people have nothing to disclose: Francis P. Robertson, Pulathis Siri-wardana, Paul R. Bessell, Rafael Diaz-Nieto, Nancy Rolando, Brian R. Davidson Introduction: Obesity affects more than one third of Americans. Morbid obesity (body mass index (BMI) >35 kg/m2) has been associated with multiple co-morbidities and perioperative complications.