LY3039478 results The participating postmenopausal women were Caucasian and ranged in age from 57 to 74 years (mean ± SD age 65 ± 6.3 years). For urine NTX (Table 1, Fig. 1), CVs varied from 5.4% to 37.6%: CVs were 5.4% (95% CI 3.2–15.5) for ARUP, 8.0% (CI 4.5–30.4) for Esoterix,

this website 25.9% (CI 15.2–87.9) for LabCorp, 8.6% (CI 5.1–25.0) for Mayo, 6.6% (CI 3.9–19.1) for Quest, and 37.6% (CI 21.6–168.0) for Specialty. Table 1 Longitudinal reproducibility of urine NTX Lab Assay Reference rangea Mean ± SD CV, % (95% CI) ARUP Vitros ECi 26–124 35.8 ± 1.9 5.4 (3.2–15.5) Esoterix Vitros ECi 25–110 35.8 ± 2.9 8.0 (4.5–30.4) LabCorp Osteomark 5–65 74.2 ± 19.3 25.9 (15.2–87.9) Mayo Vitros ECi 19–63 35.0 ± 3.0 8.6 (5.1–25.0) Quest Vitros ECi 4–64 34.0 ± 2.2 6.6 (3.9–19.1) Specialty Osteomark 14–74 42.8 ± 16.0 37.6 (21.6–168.0) Vitros ECi (all) PRN1371 in vivo   35.1 ± 2.5 7.2 (5.5–10.6) Osteomark (all)

  58.5 ± 17.7 30.3 (20.4–60.5) Units for reference ranges, means and SDs: nM BCE/mM Cr aReference ranges, provided by each laboratory, are for postmenopausal women for ARUP and Esoterix, premenopausal women for Mayo and Quest, and not specified for LabCorp and Specialty Fig. 1 Urine NTX measurements for the six laboratories. Send-out rounds were of identical specimens and were 6 to 7 weeks apart, with the exception

of those sent to Specialty, for which the interval between the first and second dates was 14 weeks For BAP (Table 2, Fig. 2), longitudinal CVs ranged from 3.1% (CI 1.9–9.1) for Esoterix to 23.6% (CI 13.9–77.2) for LabCorp. Neratinib supplier Analyses using perturbed data, done because some labs’ results were in whole numbers and some to one tenth of a microgram per liter or unit per liter, gave similar results. For example, the longitudinal CV for Esoterix, which reported its results as whole numbers, became 4.5% (CI 2.7–13.0) when the values were perturbed by random variables before computations were performed, and the CV for LabCorp, which reported its results to a tenth of a microgram per liter, became 24.3% (CI 14.3–80.2) when the values were rounded to whole numbers before computations were performed. Table 2 Longitudinal reproducibility of serum BAP Lab Assay Reference rangea Mean ± SD CV, % (95% CI) ARUP Ostase 7.0–22.4 13.8 ± 1.3 9.3 (5.6–27.3) Esoterix Ostase ≤22.4 14.2 ± 0.4 3.1 (1.9–9.1) LabCorp Ostase 0.0–21.3 11.4 ± 2.7 23.6 (13.9–77.2) Mayo Ostase ≤22 14.4 ± 0.9 6.2 (3.7–18.0) Quest Ostase 5.6–29.0 14.4 ± 1.5 10.4 (6.2–30.7) Specialty Metra BAP 14.2–42.7 24.0 ± 1.4 5.6 (3.4–16.3) Ostase (all)   13.6 ± 1.6 11.4 (8.9–16.0) Metra BAP   24.0 ± 1.4 5.6 (3.4–16.