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“Objective: Analysis of the clinical, audiometric, radiologic, and genotypic characteristics of a cohort of Southeast Asian patients with hearing loss (HL) associated with enlarged vestibular aqueduct (EVA).
Patients: Ten consecutive children with sensorineural
HL and EVA detected on computed tomographic scanning of the temporal bone.
Interventions: Audiometric, radiologic, and genetic analysis of the patient cohort of 10 children.
Main selleck kinase inhibitor Outcome Measures: Audiometric, radiologic analysis. Genetic analysis to assess for the presence of Connexin 26, Connexin 30, A1555G, and Pendrin gene variants.
Results: The novel 1693insA and 1521delT variants were identified in our study group. When both loci were considered simultaneously, 8 (80%) of 10 patients studied carried variants in either
the pendrin (n = 5) or connexin 26 (n = 6) genes. When analyzing (using the Mann-Whitney U test) for a correlation between an increased NU7441 clinical trial probability of either a larger VA, bilateral EVA, or higher rate of progression of HL in the presence of pendrin or connexin 26 gene variants (as opposed to the absence of these variants), there was no statistically significant difference found. This differs from other studies where there was a significantly wider VA and a wider vestibule in subjects with pendrin mutations.
Conclusion: There is a significant delay in the diagnosis of EVA in children with HL in our Southeast Asian population. An increased awareness of EVA as a differential diagnosis among professionals managing these children is important to reduce this delay.”
“The reconstruction of intraoral defects can be challenging due to the different characteristics of the region, importance of preserving the anatomy and function, and shortage of available donor areas. The location and size of the defect guides the reconstructive surgeon through the treatment plan. Among the options available, tongue flaps have been found useful
in intraoral defect reconstruction.
In this study, we NVP-AUY922 presented the use of tongue flaps in different kinds of intraoral defects, and compared the advantages and disadvantages with other methods. Between 2004 and 2011, tongue flaps were used in intraoral reconstruction of 11 patients ( 6 male and 5 female) with a mean age of 30.1. Six patients had palatal fistula, 3 had alveolar region and mouth floor defects, and 2 had lower lip defects. All of the tongue flaps planned were anterior based, 6 dorsal and 5 ventral. Second operations were carried out on the 15th or 20th postoperative days.
Despite the disadvantages of being an interpolation flap which requires a second session and good patient cooperation, tongue flap is a choice for reconstruction of intraoral defects with its highly vascular structure, good mobility, localization, texture match, and low donor area morbidity.