01). Rehaemorrhagia rate and death rate in aged patients is also significantly higher than in younger patient s (P < 0.05). Conclusion: UGB in elderly patients is mainly

caused by peptic ulcer, acute gastric mucosal lesion and digestive tract cancer. There are not known contributing causes for UGB in most elderly patients, but risk of UGB is high in the elderly patients used non-steroids or glucocorticoid. Their clinical symptoms largely is hypo-perfusion of peripheral circulation and tarry stool, and upper abdominal pain with minority. There are more chronic diseases, complications, rehaemorrhagia rate and death rate in aged patients. Key Word(s): 1. Elderly patient; 2. lbleeding; 3. Clinical feature; Presenting Author: SUBASH GAUTAM Additional Authors: GURRUP GAUTAM Corresponding Author: SUBASH GAUTAM Affiliations: FUJIARAH HOPITAL Objective: Gall stones is not uncommon due to various factors in pregnancy, patients who developed acute cholecystitis Epigenetics inhibitor or billary colic during pregnancy were randomized to laproscopic cholecystectomy or conservative management. Methods: from jan 2006- dec 2009, randomization of pregnant MLN8237 order patients with biliary disease-mainly biliary colic and acute cholecystitis, in three trimesters, outcome of pregnancy and management was studied. Results: there were total 17 patients in each group, mean age 27years, 4 patients in first trimester, 6 in second trimester and 7 in third trimester, 6

patients in conservative treatment group had to be transferred to operative group,

one patient in conservative group had abortion in first trimester, no adverse outcome in operative group. Conclusion: laproscopy in any medchemexpress trimester is safe, it should be offered to all patient with informed consent. Key Word(s): 1. laproscopy; 2. pregnant; 3. cholecystectomy; 4. safe; Presenting Author: NIKOLAOS VASSOS Additional Authors: ABBAS AGAIMY, WERNER HOHENBERGER, ROLAND CRONER Corresponding Author: NIKOLAOS VASSOS Affiliations: Department of Surgery, University Hospital Erlangen, Germany; Department of Pathology, University Hospital Erlangen, Germany Objective: Over the last decade, several changes occurred in the diagnostics, treatment and understanding of pathogenesis of the gastrointestinal stromal tumors (GIST). However, their coexistence with other malignancies of different origin remains a challenging situation during the interdisciplinary management of GIST-patients. Methods: Patients diagnosed with GIST in a 10-years period (2000–2009) were identified retrospectively and clinical history and findings thoroughly explored for the presence of associated other malignancies. Follow up data were obtained and analyzed for prognostic impact of the concurrent malignancy and/or GIST. Results: Thirty six (26 male, 10 female) of 86 GIST patients (42%) were associated with other malignancies (n = 41). The mean age was 70 years (range, 56–86).