26 Intractable ascites after abdominal surgery occurs in approximately 40% of CTP-B patients, and even in 5% of CTP-A patients.29 AZD6738 price Eighty per cent of head and neck surgery patients who

were CTP-B and C developed complications. Risk factors for poor outcome included preoperative platelet transfusion, intraoperative blood transfusion, intraoperative blood loss > 500 mL, CTP score, serum albumin concentration, and prothrombin time.25 The morbidity of laparoscopic cholecystectomy in cirrhosis (mainly CTP-A) was 15% in a study from Pakistan, with complications such as ascites and bile leakage.20 In cardiac surgery, figures for significant morbidity of 31% have been reported in CTP-B patients.27 An approach to the management of a cirrhotic patient requiring elective surgery is shown in Figure 1. A physician experienced in managing liver disease should assess the patient prior to elective surgery. They should calculate the CTP and MELD score, assess nutritional status and determine if there is significant portal hypertension.1,6

It is important that this takes into consideration recent improvements or deterioration of liver function. For example, a CTP-B patient may be re-categorized to CTP-A with medical management, but the surgical risks may remain more in keeping with their poorer underlying liver function that conferred the recent CTP-B status. Many patients with chronic liver disease have malnutrition, and if this is of concern, dietitian advice and dietary supplements, such as a late evening snack prior to the procedure may Palbociclib cost be of benefit.35 Vitamin K stores may be low, and 10 mg of vitamin K should be administered intramuscularly or intravenously. In patients with severe or refractory C59 price ascites, preoperative TIPS with semi-elective repair is an option that may improve outcomes.36 The expectations of the patient and their family must be managed. In particular, they must be prepared for the possibility of a prolonged postoperative hospital stay due to complications and be aware of the 30-day mortality, particularly when considering elective

surgery or in weighing surgical versus non-surgical options. Accurate measurement of portal pressures, such as by wedged hepatic venous gradient, may be useful to guide surgical management in some cases as the presence/absence of significant portal pressure does influence surgical outcomes.37 Preoperative assessment prior to hepatic resection has used the indocyanine green retention test (ICG clearance) as a predictor of mortality in hepatic resection surgery. This is not commonly used for surgery other than partial hepatectomy.30–32 In some series it has been shown to be superior to CTP status, but other studies have suggested that there is no added benefit of ICG clearance.33 Prediction of liver failure after hepatic surgery has been summarized in two reviews by Schneider,34 and by Garcea et al.,33 but is beyond the scope of this discussion.