3 %).50 Furthermore, in five studies in which adults were systematically screened for BDD, no patient who was found by the Small molecule library researchers to have BDD had the diagnosis of BDD in their medical record.7-11 The number of patients found to have BDD were as follows: 30 of 30, 11 of 80, 16 of 122, 10 of 208, and 16 of 122. Demographic characteristics BDD has been reported to occur in children as young as 5 and in adults as old as 80. 6,51 Regarding gender ratio, the two largest population-based studies of BDD (one conducted in the US;

n=2048, and the other conducted in Germany; n=2552) found a point prevalence of 2.5% of women vs 2.2% of men, Inhibitors,research,lifescience,medical and 1.9% of women and 1.4% of men, respectively.28,30

The largest clinical samples of persons ascertained for BDD contained an equal proportion of females and males (49% of 188 participants were female)52 or a somewhat higher proportion of females Inhibitors,research,lifescience,medical (68.5% of 200 participants).53 Thus, BDD may be somewhat Inhibitors,research,lifescience,medical more common in women, but it clearly affects many men as well. The two population-based studies cited earlier found that individuals with BDD are less likely to be married than those without BDD,28,30 and are more likely to be divorced. Individuals with BDD are also significantly more likely to be unemployed than the general population.28,30 In a sample of 200 individuals with BDD, 37.6% were currently unemployed.54 Case description Ms A, a 32-year-old single white female, was referred by her dermatologist to a BDD specialty clinic. She lived alone, was not involved in a romantic relationship, and had no children. Inhibitors,research,lifescience,medical Despite having completed college, she was employed as a part-time clerk in a clothing boutique. Ms A attributed her difficulties with obtaining

full-time work to interference she experienced from intrusive thoughts and compulsive behaviors related to her appearance concerns. Ms A looked Inhibitors,research,lifescience,medical normal but had been preoccupied with the appearance of her skin (minor blemishes and “uneven” skin tone) since age 13. She reported thinking about her appearance for at least 7 to 8 hours a day, and she worried that Isotretinoin other people would notice her or judge her negatively because her skin looked so “ugly.” For 5 to 6 hours a day, Ms. A checked her skin in mirrors and other reflecting surfaces, picked her skin, and compared her skin with that of other people. She spent thousands of dollars a year on skin-care products, and she frequently bought special lighting and mirrors to better examine her skin. Because she was so preoccupied with, and distressed by, her skin, Ms A was often late for work, and her productivity suffered, which resulted in conflicts with her supervisor. She often got “stuck” in the mirror at work, examining her skin.