6); 38.5% were female.

The most common diagnoses were lung (n=13), colon (n=12) or breast (n=11) cancer, with 74 patients having at least one comorbidity (e.g. hypertension, diabetes). In the patient group cared for by PAMINO-trained GPs, 56% of the patients had an ECOG PS of 3 or 4. In the control group of patients cared for by other GPs 49% of the patients had an ECOG PS of 3 or 4. About 40% of patients in both groups have had a hospital consultation within the month prior to the study assessment; 7 patients were in contact with palliative care services (including physician, nursing, palliative care unit, and hospice). There were no Inhibitors,research,lifescience,medical statistically significant differences between patient groups. Figure 1 Flowchart of study participants and available data. Table 1 Sample Inhibitors,research,lifescience,medical characteristics of GPs in PAMINO (PG) and control group (CG) Table 2 Patient characteristics of palliative patients The QLQ-C15-PAL and the POS are both self-administered questionnaires measuring quality of life. More than half of the patients (PG: 52%, CG: 63%, p=.33) needed help from either family/friends or staff to fill out the questionnaires. ‘Overall quality Inhibitors,research,lifescience,medical of life’ and POS sum score Patients reported a mean quality of life on the QLQ-C15-PAL of 38.1 (SD=25.7, n=87) and on the POS of 13.0 (SD=6.1, n=83). Of 76 patients, both questionnaires were available. ‘Overall quality of life’ (QLQ-C15-PAL) and POS sum score correlated highly (r=−.59, p<.01). On

the QLQ-C15-PAL, mean QoL of the patient groups of PAMINO-trained and other GPs were 37.7 (SD=25.5, n=54) Inhibitors,research,lifescience,medical and 39.4 (SD=26.3, n=33) (p=.76), respectively. On the POS, respective mean values of 13.6 (SD=5.8, n=51) and 12.0 (SD=6.5, n=32) (p=.26) were given. Patients cared for by a PAMINO-trained GP did not report better QoL Inhibitors,research,lifescience,medical and care outcomes than patients cared for by another

GP. The results of the univariate analyses were confirmed in regression models using practice as cluster variable and group, ECOG PS, gender and age of the patient, and experience of the GP as independent variables. Due to missing values, the models were analyzed with n=81 and n=78 for ‘Overall quality of life” and the POS sum score, respectively. Only the ECOG PS significantly influenced the two scales: Compared to patients with a ECOG PS of 4, patients with a ECOG PS of 0, 1 or 2 had a higher ‘Overall quality of life’, and patients with a ECOG PS of 0 or 1 had a lower POS sum score. QLQ-C15-PAL PKA inhibitor cell line function and symptom scales On the function scales, patients in both no groups reported a higher emotional functioning (M=46.9, SD=34.4, n=95) than physical functioning (M=30.1, SD=34.5, n=92). Additionally, physical functioning was skewed towards the lower end of the scale (median=13.3). The most prevalent symptoms were fatigue (M=74.4, SD=30.1, n=94), appetite loss (M=55.1, SD=40.3, n=95) and pain (M=51.1, SD=36.2, n=95). Patients in both groups did not differ in their perception of function and symptoms (Table 3).