All authors reviewed and contributed to the final manuscript. The authors gratefully thank Jennifer Beck for her helpful comments, and Norman Comptois for his technical advice with recordings of the electrical activity of the crural diaphragm. This work Tyrosine Kinase Inhibitor Library mouse was supported by research grants from the Veterans Administration Research Service. Dr. Daniel Morales was supported by a grant of the ‘Comision Nacional de Investigacion Cientifica y Tecnologica’ (CONICYT) of Chile. The funding agencies had no role in study design,
data collection and analysis, decision to publish, or preparation of the manuscript. “
“The authors regret for the missed legend in the Fig. 2. The below provided figure replaces the former Fig. 2 where of the blood pressure legend was incorrect. “
“The publisher regrets that due to an error in production Table 1 was not reproduced correctly. GSK126 supplier The corrected Table 1 appears below. The publisher would like to apologise for any inconvenience caused. “
“Two separate
systems for the dynamic testing of both commercial and in-house constructed fast response time fibre optic oxygen sensors have been described recently. The first system (Saied et al., 2010) described a gas chamber apparatus for testing the time response and performance of fast commercial optical sensors in the gas phase; the second system (Chen et al., 2012b) described a hand-controlled fluid flow cross-over apparatus for testing fast response time fibre optic blood-gas sensors in the liquid phase. We describe here a computer controlled system for simulating rapid breath-by-breath induced changes in arterial oxygen partial pressure (PaO2)(PaO2)
in response to intra-breath changes in pulmonary shunt in the lung, which are induced by cyclical atelectasis, and for testing the capability of intravascular oxygen sensors to measure these fast changes in PaO2PaO2 accurately. Cyclical atelectasis is a phenomenon in the lung whereby part of the lung collapses during expiration and then re-opens on inspiration (Duggan and Kavanagh, 2005). When the lung partly collapses, venous admixture occurs and the arterial blood PO2PO2 falls, only to rise again as Interleukin-3 receptor the lung opens up again on inspiration. This cyclical opening and collapsing of the lung during mechanical ventilation of the sick lung can cause further injury – known as Ventilator Induced Lung Injury (VILI) (Albert, 2012 and Fan et al., 2013). The presence of oscillating PaO2PaO2 may therefore serve as a physiologically important biomarker of cyclical atelectasis, and the design of an intravascular oxygen sensor to detect it presents a major diagnostic opportunity. Such sensors need to be more than an order of magnitude faster than the relatively slow, and now historic, electrochemical sensors that were first used to investigate cyclical atelectasis in an animal model (Williams et al., 2000).