Arterial compliance was characterized by cerebral pulse transit time derived from phase difference analysis between ECG and TCD signals. Sleep time was dichotomized into periods with high density of consecutive respiratory events vs. periods with low density of consecutive respiratory events. TCD measurements of CBF velocity showed a regular, undulating pattern with flow minima immediately before apneas or hypopneas and maxima closely after their termination, reciprocally to peripheral O2 saturation.

CBF velocity reactivity was significantly diminished in consecutive respiratory events compared to non-consecutive respiratory event periods. The authors discussed severe disturbances of cerebrovascular reactivity in OSAS patients and interpreted their data as a sign of loss of vasoreactivity and increase of arterial stiffness. The combined long-term recordings of intracranial High Content Screening Talazoparib cell line flow patterns

and polysomnography constitute an important method for evaluating dynamic aspects of brain function and cerebral perfusion during sleep. Numerous studies concerning this scientific field using this technique have contributed to a better understanding of the physiology of the normal sleep and the pathophysiology of sleep disorders as well as that of nocturnal stroke. “
“The mechanism of cerebral autoregulation (CA) minimizes fluctuations of cerebral blood flow (CBF) during changes of cerebral perfusion pressure (CPP). Pressure triggered dilatation or constriction of small artery vessels may control cerebral blood flow resistance and prevent the brain from ischemia during decrease as well as from hyperemia during increase of CPP. This so-called cerebrovascular pressure reactivity (CVR) is a pre-condition of a working CA. While cerebral autoregulation is characterized by its regulating effect on cerebral blood flow, CVR describes the state of its underlying mechanism. Since CA may be affected in patients with severe brain injuries [1] and [2] its monitoring

provides important information for clinical treatment. Various monitoring methods are based on the concept of dynamic CA [3] which not NADPH-cytochrome-c2 reductase only describes a steady-state relationship between CPP and CBF [1] but also assesses the flow dynamics during rapid pressure changes. During monitoring these pressure changes may either be induced under controlled conditions [4] and [5] or due to spontaneous oscillations of ABP or CPP [6] and [7]. In recent publications the question whether CA was symmetric, i.e. whether CA response was equally effective during increase and decrease of pressure challenge, was subject to investigation and partly contradictive results. For the first time Aaslid reported a stronger response of dynamic autoregulation during increasing ABP compared to decreasing ABP [8]. This effect was demonstrated in 14 patients with traumatic brain injuries (TBI) during cyclic changes of ABP which have been induced by sequentially repeated leg cuff tests.