Depending on the availability, we will also include other clinical centers

to validate our findings. We will include all consecutive medical patients including patients with neurological admission diagnoses presenting to ED for medical reasons and follow them during the hospital course until hospital discharge. There Inhibitors,research,lifescience,medical will be no exclusions except for non-adult and non-medical patients. Clinical information and PFT�� chemical structure assessment outcomes We will record initial vital signs (i.e. blood pressure, respiratory rate and others) and clinical parameters (i.e. main complaint, initial diagnosis) in the ED and collect left over blood

samples Inhibitors,research,lifescience,medical in all patients. Clinical information including socio-demographics and comorbidities, patient outcomes and nursing information using the “Selbstpflegeindex” (SPI) and the PACD will be assessed prospectively until hospital discharge using the routinely gathered information Inhibitors,research,lifescience,medical from the hospital electronic medical system used for coding of Diagnosis-Related Groups (DRG) codes. This already available information supports the reliable assessment

of baseline characteristics including Inhibitors,research,lifescience,medical demographics, comorbidities, acute medical conditions requiring the ED visit and different patient outcomes including inhospital mortality, resource use in terms of admission to the intensive care unit, length of stay (LOS) in the hospital and overall costs. We will also collect information about care needs in case of transfer to another post-acute institution after hospital discharge. Inhibitors,research,lifescience,medical We will Histone demethylase contact all patients by phone interview 30 days after admission to evaluate vital and functional status, care needs at home, rehospitalisation rates, satisfaction with care, preparedness for discharge,quality of life measures using the EQ-5D questionnaire [36] and EQ VAS among others. Daily assessment of clinical stability with the “Visitentool” We will assess clinical stability of patients daily during the medical rounds. We have developed an online computer-based stability assessment tool – called “Visitentool” – where patient’s stability and readiness for hospital discharge must be entered daily on clinical rounds.