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59. Boutros N, Gonullu N, Casetta A, Guibert M, Ingrand D, Lebrun L: Ralstonia pickettii traced in blood culture bottles. J Clin Microbiol 2002,40(7):2666–2667.PubMedCrossRef 60. Coenye T, Spilker T, Martin A, LiPuma Danusertib cost JJ: Comparative assessment of genotyping methods for epidemiologic study of Burkholderia cepacia genomovar III. J Clin Microbiol 2002,40(9):3300–3307.PubMedCrossRef Authors’ contributions MPR conceived the study and its design, carried out the experimental work, performed the analysis and interpretation of the data and wrote the manuscript. JTP participated in conceiving the study and in its design and participated in writing the manuscript. CAA participated in conceiving the study, its design, and participated in writing www.selleckchem.com/products/s63845.html the manuscript.

All authors Chloroambucil read and approved the final manuscript. The authors declare no conflict of interest.”
“Background The human gut microbiome is a complex ecosystem harbouring a rich diversity of commensal microorganisms. It is widely thought that the early life development of the neonatal intestinal microbiota

plays an important role in the maturation of the host immune system and could in turn Emricasan nmr influence allergy development [1–3]. For example, germfree mice which lack the endemic intestinal microbiota showed impairment of intestinal mucosal and systemic immune system development. The impairment in the systemic immune system is reflected by poorly formed spleen and lymph nodes, hypoplastic Peyer’s patches, reduced levels of secreted IgA and IgG, and lack of expansion of CD4+ T cell populations [2, 3]. Furthermore, these mice exhibited cytokine profiles that skewed towards Th2 [2], which is involved in the pathophysiology of allergic diseases. Past studies have further reported that intestinal microbiota in subjects with allergy, particularly those with atopic eczema, differed from those of healthy controls [4–7]. Wang and colleagues showed that there is a reduced bacterial diversity in the early stool microbiota of infants with atopic eczema [7]. Recently, we further showed that the abundances of Bifidobacterium and Enterobacteriaceae were different among caesarean-delivered infants with and without eczema [5].