In addition, histologically higher grades of osteoarthritis (Osteoarthritis Research Society International – OARSI grading), and significantly find protocol decreased levels of chondroitin sulfate and hyaluronic acid. Knee cartilage thickness and TUNEL did not significantly differ between the two groups.
Conclusions: The articular cartilage of rats subjected to a strenuous running regimen of controlled intensity exhibited molecular and histological characteristics
that are present in osteoarthritis. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“SETTING: National tuberculosis (TB) programmes (NTPs) in 100 countries.
OBJECTIVES: To evaluate the relationship between the estimated prevalence of multidrug resistance in previously untreated TB cases and policies regarding sales and distribution of TB drugs, particularly rifampicin (RMP). DESIGN: Questionnaire survey of national TB drug control policies, completed by NTP managers. Results were correlated with recent World Health Organization
estimates of prevalence of drug resistance in new cases of TB.
RESULTS: Questionnaires were received from 100 countries, including 88 low- and middle-income countries (LMICs) and 17 of the 22 high-burden countries. Current policies were considered adequate in only 40 of the 88 LMICs (45%). A higher prevalence of multidrug resistance was associated with fewer years of free availability of TB drugs from the NTP (P = 0.02) and more years of availability of RMP from providers or pharmacies outside the NTP (P GDC-0994 inhibitor =
0.02). Eleven of the 20 countries with the highest prevalence of multidrug resistance had inadequate policies governing sales and distribution of TB drugs.
CONCLUSIONS: These findings suggest that policies regarding BEZ235 sales and distribution of TB drugs should receive more emphasis as part of the global strategy to control drug resistance.”
“Background/rationale: Introducing new or testing existing drugs in an attempt to modify the progress of osteoarthritis (OA) is of paramount importance.
Questions/purposes: This study aims to determine the effect exerted by Calcitonin on the progress of early-stage osteoarthritic lesions.
Methods: We used 18, skeletally mature, white, female, New Zealand rabbits. OA was operatively induced in the right knee of each animal by the complete dissection of the anterior cruciate ligament, complete medial meniscectomy and partial dissection of the medial collateral ligament. Postoperatively, animals were divided into two groups. Starting on the ninth postoperative day and daily thereafter, group A animals (n = 9) received 10 IU oculus dexter (o.d.) of synthetic Calcitonin IntraMuscularly (I.M.); group B animals (n = 9) received equal volume of saline o.d. Three animals from each group were sacrificed at 1,2 and 3 months following treatment’s initiation.