MeasurementsChange in self-reported
ADHD symptoms, relapse to any drug use (amphetamine and other drugs) measured by urine toxicology, retention to treatment, craving and time to relapse.
FindingsThe MPH-treated group reduced their ADHD symptoms during the trial (P=0.011) and had a significantly higher proportion of drug-negative urines compared with the placebo group (P=0.047), including more amphetamine-negative APR-246 urines (P=0.019) and better retention to treatment (P=0.032).
ConclusionsMethylphenidate treatment reduces attention deficit hyperactivity disorder symptoms and the risk for relapse to substance use in criminal offenders with attention deficit hyperactivity disorder and substance dependence.”
“Objective: To formulate and evaluate solid-reversed-micellar-solution (SRMS)-based solid lipid microparticles (SLMs) for intramuscular administration of gentamicin.
Methods: SRMS formulated with Phospholipon (R) 90G and Softisan (R) 154 were used to prepare gentamicin-loaded SLMs. Characterizations based on size and morphology, stability and encapsulation efficiency (EE%) were carried out on the SLMs. In vitro release of gentamicin from the SLMs was performed in phosphate
buffer while in vivo release studies were conducted in rats.
Results: Maximum EE% of 90.0, 91.6 and 83.0% were obtained for SLMs formed with SRMS 1: 1, 1: 2 and 2: 1, respectively. Stable, PLX4032 purchase spherical and smooth SLMs of size range 9.80 +/- 1.46 mu m to 33.30 +/- 6.42 mu m were produced. The release of gentamicin in phosphate buffer varied widely with the lipid contents. Moreover, significant (p < 0.05) amount of gentamicin was released in vivo from the SLMs.
Conclusion: SRMS-based SLMs would likely offer a reliable means of delivering gentamicin intramuscularly.”
“The accurate and reliable estimation of fiber orientation distributions,
based on diffusion-sensitized magnetic resonance images is a major prerequisite for tractography algorithms or any other derived statistical analysis. In this work, we formulate the principle of fiber continuity C188-9 (FC), which is based on the simple observation that the imaging of fibrous tissue implies certain expectations for the measured images. From this principle we derive a prior for the estimation of fiber orientation distributions based on high angular resolution diffusion imaging (HARDI). We demonstrate on simulated, phantom, and in vivo data the superiority of the proposed approach. Further, we propose another application of the FC principle, named FC flow, a method to resolve complex crossing regions solely based on diffusion tensor imaging (DTI). The idea is to infer directional information in crossing regions from adjacent anisotropic areas.”
“Objectives: Correlate adenoid size as determined by lateral neck radiographs and intra-operative mirror exam. Determine if a radiologist’s assessment of the lateral neck X-ray correlates with adenoid size.