\n\nResults and limitations: In clinical analyses, a predictive model consisting of smoking history (p = 0.040), T stage (p < 0.0001), Fuhrman grade (p < 0.0001), Eastern Cooperative Oncology Group performance status (p < 0.0001), and microvascular invasion (p < 0.0001) was independently associated with lymphatic spread. After adjustment with these clinical variables, low carbonic anhydrase IX (CAIX) (p = 0.043) and high epithelial vascular

endothelial growth factor receptor 2 (p = 0.033) protein expression were associated with a higher risk of lymphatic spread, and loss of chromosome 3p (p < 0.0001) with a lower risk. The current study is limited by its retrospective design, small sample size, and single-center experience.\n\nConclusions: The low rates of CAIX expression and loss of chromosome LDK378 3p suggest that lymphatic spread in ccRCC occurs independently of von Hippel-Lindau tumor suppressor inactivation. (C) 2012 European Association of Urology. Published by Elsevier B. V. All rights reserved.”
“This paper describes a simple methodology for simulating single-event effects, including soft error rates, of bulk complementary metal-oxide semiconductor integrated circuits. The induced currents due to ion strikes are derived from the basic carrier transport equations and then used in simple SPICE simulations. The 3-D equations

were reduced to AC220 in vitro a 1-D problem. This method is much less expensive than 3-D TCAD for predicting

single-event effects, especially when several types of circuits or several critical circuit paths must be investigated. The upset conditions for two SRAMs are simulated, and the results compare well with experiments. A simple method for predicting the soft error rate is also described, including a method for calculating the dimensions of Volasertib in vivo the sensitive volumes for a given circuit.”
“A study included 113 patients with localization-related epilepsy treated with antiepileptic drugs: 53 patients with drug-resistant (uncontrolled) form of the disease and 60 patients with controlled epileptic seizures. A comparison group included 53 patients with rare seizures not taking antiepileptic drugs. In the group of patients with uncontrolled localization-related epilepsy, the EEG monitoring of the sleep-wake cycle revealed more frequent regional interictal epileptiform discharges and increased alpha- and beta-activities during sleep compared to wakefulness. In patients with controlled seizures, there were the circadian changes in intra- and inter-hemispheric coherent relations in theta- m beta-bands. These relations remained stable when the sleep phase was changed to the wake phase.”
“Background: In clinical practice it can be observed that some patients with seasonal allergic rhinitis (AR) continue to have symptoms even when the exposure to allergens is expected to be low or absent.