Results: On average, patients with AIH,
PBC and AIH-PBC OS were more common in women than in men. The average age of patients before 2007 was older than after 2007 among the three groups. Most clinical features are not typical. Inhibitor Library screening The incidence of cirrhosis was 43.5%(57/131) in AIH, 42.3%(36/85) in PBC and 38.8%(19/49) in AIH-PBC OS at the first visit. and it was higher before 2007 than later. Most liver cirrhosis has reached decompensatory stage: AIH 80.7%(46/57), PBC 75.0%(27/36)and AIH-PBC OS 57.9%(11/19). ALT, AST and IgG levels were markedly elevated in patients with AIH, whereas ALP, GGT and IgM levels were elevated in PBC. The differences among the 3 groups have statistical significance. The positive rate of SMA was highest in AIH which was 17.6%(23/131) while the positive rate of AMA was highest in PBC which was 100%(49/49). The differences among the 3 groups have statistical significance. AIH-PBC OS had the pathological characteristics of both PBC and AIH. The difference among the three groups was statistically significant. Compared with PBC, pathological characteristics of AIH-PBC OS was more inclined to AIH. Conclusion: The average age of onset of AIH, PBC and AIH-PBC OS is getting younger in recent years.
Most patients presented liver cirrhosis of decompensated stage at the first visit. Change of blood biochemical and immunological indexes and pathological conditions of liver have the important reference value for clinical diagnosis. Key Word(s): 1. autoimmune liver ; 2. Overlap syndrome; 3. Clinical features; Metabolism inhibitor 4. pathological ; Presenting Author: YU-MING WANG Additional Authors: WEN-TIAN LIU, LU ZHOU, BANG-MAO WANG Corresponding Author: YU-MING WANG Affiliations:
Tianjin Medical University General Hospital Objective: Introduction:A 24-year-old man with recurrent jaundice was admitted because of acute high fever and subsequent deterioration of liver function companied with significant jaundice. Methods: Case description: Microscopically, the liver showed liver cell necrosis companied with extensive intrahepatic cholestasis, medchemexpress capillary bile thrombus formation, slight portal area fibrosis and a few lymphocytes infiltration. The periportal was small, and absence of interlobular bile duct (three portal areas were seen, but only one of which companied with interlobular bile duct ). Immunohistochemical staining showed that SMA was positive in Small vessels of portal area, CK was positive in Small vessels of portal area, and the Small bile duct basement membrane was silver stained. The patient made an uneventful post admitted recovery. The level of serum bilirubin and other Liver enzyme underwent a Tortuous change, which were characterized whit significant jaundice and severe intrahepatic cholestasis. The IgM of CMV was positive, and the nuclear antigen and viral capsid antigen of EBV were positive.