Summary
The ultimate goal of implementing a multipronged
osteoporosis preventive program is to improve function and quality of life in later life.”
“Objective: To determine whether the prevalence of mental disorders and related factors increase as advanced cancer patients get closer to death.
Method. Baseline, cross-sectional data from 289 patients who were assessed prior to their death as part of a multi-site, longitudinal, prospective cohort study of advanced cancer patients. Major depressive disorder, generatized anxiety disorder, panic disorder, and posttraumatic stress disorder were assessed using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-IV Axis I Disorders. Other factors examined included existential well-being, patient grief about their illness, physical AC220 cost symptom burden, terminal illness acknowledgment, peacefulness, and the wish to live or die.
Results: Closeness to death was not associated with higher rates of mental disorders. Patients closer to death exhibited increased existential distress and physical symptom burden, were more likely to acknowledge being terminally ill, and were more likely to report an increased wish to die.
Conclusion: Results do not provide support for the common clinical assumption that the prevalence of depressive and anxiety disorders increases as death nears. However, patients’
level of physical distress, acknowledgment of terminal illness, and wish to die, possibly reflecting acceptance of dying, increased as death approached. Longitudinal studies www.selleckchem.com/products/ABT-263.html are needed to confirm individual changes in rates of mental disorder as patients approach death. Copyright (c) 2008 John Wiley & Sons, Ltd.”
“Purpose of review
Several recent clinical trials and systematic reviews have examined functional outcomes of exercise programs in two populations: older adults and adults with knee arthritis. We synthesize recent clinical trials and systematic reviews to examine whether the links between
exercise and functional outcomes are better understood than they were a decade ago.
Recent findings
Systematic reviews Selleckchem Ferrostatin-1 and current clinical trials reveal a modest beneficial effect of progressive resistance training (strengthening programs) and aerobic programs on strength, pain, and function in both populations. Few randomized controlled trials have investigated disability-level outcomes, and of those that do examine disability outcomes, the majority of studies have not shown a beneficial effect.
Summary
Current and recent evidence shows little to no impact of exercise on the prevention of disability. Exercise programs may need to be changed if the desire is to prevent or minimize disability. Alternatively, different strategies need to be developed to address disability more directly.