Table 4 Body Water Variables Variables Day 0 Day 6 Day 27 Day 48 Total Body Water (L) * (p = 0.022) * (p = 0.001) PLA 42.36 (8.68) 43.32 Everolimus (7.86) 44.23 (8.56) 44.79 (7.49) CRT 46.34 (6.38) 46.74 (6.72) 47.62 (7.16) 48.98 (7.28) CEE 41.51 (5.77) 42.32 (5.36) 43.11 (6.20) 43.46 (6.10) Intracellular
Body Water (L) * (p = 0.023) * (p = 0.001) PLA 24.90 (5.94) 26.15 (4.77) 26.57 (5.04) 27.42 (4.30) CRT 27.91 (3.97) 28.19 (3.96) 29.05 (4.53) 30.43 (4.62) CEE 25.03 (3.98) 24.90 (3.78) 25.87 (4.11) 26.04 (4.03) Extracellular Body Water (L) * (p = 0.042) PLA 16.94 (3.80) 17.12 (3.30) 17.66 (3.79) 17.36 (3.29) CRT 18.44 (2.52) 15.56 (2.87) 18.58 (2.71) 18.55 (2.73) CEE 16.47 (2.06) 17.42 (1.71) 17.25 (2.20) 17.42 (2.24) Data are expressed as mean (± SD). * indicates a significant Enzalutamide cell line difference at the respective testing session (p < 0.05). Muscle strength For bench press strength, AMG510 cost no significant difference was observed between groups (p = 0.946); however, a significant difference among the four testing sessions existed indicating that bench press strength was significantly increased at days 27 (p = 0.001) and 48 (p = 0.001). No significant difference between groups was observed for leg press strength (p = 0.894). However, a significant difference among the four testing sessions was observed demonstrating that leg press strength increased at days 6 (p = 0.021), 27 (p = 0.001), and 48 (p = 0.001). Increases were also observed at day 27 (p = 0.001) compared to day 6 (Table 5). Table 5 Relative 1-RM Strength Variables Variable Day 0 Day 6 Day 27 Day 48 Relative Bench Press Strength * (p = 0.001) * (p = 0.001) PLA 1.04 (.26) 1.10 (.22) 1.12 (.20) 1.15 (.20) CRT 1.06 (.20) 1.06 (.22) 1.14 (.21) 1.21 (.22) CEE
1.05 (.28) 1.07 (.30) 1.10 (.29) 1.12 (.29) Relative Leg Press Strength Phosphoglycerate kinase * (p = 0.021) * (p = 0.001) * (p = 0.001) PLA 3.55 (.93) 3.70 (.99) 3.90 (.99) 3.83 (.96) CRT 3.37 (.53) 3.40 (.54) 3.72 (.66) 3.85 (.81) CEE 3.46 (.71) 3.63 (.72) 3.79 (.67) 3.87 (.72) Values are represented as means (± SD). * indicates a significant difference at the respective testing session (p < 0.05). Anaerobic Power There were no significant differences between groups for mean (p = 0.468) and peak (p = 0.705) power (Table 4). However, significant differences among the four testing sessions occurred for mean and peak power. Further analysis showed mean power to be increased at days 27 (p = 0.046) and 48 (p = 0.019), along with increases seen at day 48 compared to day 6 (p = 0.029). Peak power was increased at day 48 (p = 0.001).