The remaining 256 networks gave a positive response. The output of networks giving a positive response are of two kinds. A network commences giving a good response when the value for is some worth x 300, 301, 400 and also the value for l 100. As an illustration, if a network begins giving a constructive response once the value for is 374 and the value for l is 100, it means that, for this specific net operate with its set of edge weights , as soon the as value for exceeds 374, it will eventually give a favourable response irrespective in the concentrations on the proteins in l. A network commences providing a beneficial response when the worth for is some x 300, 301, 400 and also the value for l exceeds some value y 101, 150.

For instance, if a network starts providing a good response once the value for is 374 along with the worth for l is 105, that suggests, for this individual network with its corresponding config uration to respond positively, it’s not enough the values for just come to be 374. The value for l also requires to exceed worth 105. two Outcome our site of experiment two, From the 14187 net works, 13779 networks even now gave a damaging response. The remaining 408 networks responded positively. Which is, out of these 408 networks, each and every a single began giving good responses once the value for is some value x 300, 301, 400 as well as the value for l exceeds some value y 151, 200. That’s, by raising the preliminary concentration amount of the professional teins in l, these networks modified their response from unfavorable in Experiment one to constructive within this experi ment.

So this implies for these 408 networks, the addi tional proteins in l perform a substantial part in deciding how the network responds to your pathway. Modifying a prior detrimental response to a good 1 indicates that these a replacement proteins may well potentially be able to compensate to the lack of a number of the core protein elements inside the pathway if existing in enough amount. 3 Consequence of experiment 3, Based around the output of each network, the networks might be classified into 3 categories. The class CS represents those networks that gave optimistic responses in both Experiments two and 3 employing the exact same combination of values for its proteins. That’s, if a network gave a favourable response in Experiment two with values x since the worth for and y since the worth for l, it provides a optimistic response in Experiment three as well using the exact same mixture of values, x since the worth for and y because the value for s.

For example, if a network in CS gave a good response in Experiment two once the worth for exceeded 374 and the worth for l exceeded 105, it offers a favourable response in Experiment 3 once the worth for exceeded 374 along with the value for s exceeded 105. From the 408 networks utilized for this experiment 67 of them were positioned in class CS since of their output. The class CD represents people networks which gave optimistic responses in each Experiments 2 and three but working with the various combination of values for its proteins. As an illustration, if in Experiment 2, the network had original concentration values x for your proteins in and y for those in l, in Experiment 3 it has x as first concentration worth for proteins in and z for those in s where y z.

Such a network is positioned in class CD. From the 408 networks, 60 of them were placed in class CD. The class CN represents people networks that gave good responses in Experiment 2 but now give damaging responses in Experiment 3. 281 networks from set pos gave detrimental response and were placed in class CN. Interpretation of results 1 Experiment one, Networks that give a beneficial response once the value for is some worth x 300, 301, 400 plus the worth for l 100 indicate that for these networks with their corresponding set of edge weights, the additional proteins in l perform no considerable position in controlling their responses. The response is primarily based solely around the original concentration of your core element proteins in ?.