The standardized prevalence per 1,000 men 50 years and over in the Mexican population for the year 2005 are 65.8 (95% CI 29.9–105.5), and they are 68.6 (95% CI 32.2–108.7) in the US population for the year 2000. Table 2 Characteristics of participants Variable Mexican men n = 413 Age (mean ± sd) 68.99 ± 11.64 Height (mean ± sd) 159.77 ± 6.69 Weight (mean ± sd) 69.39 ± 12.05 Maternal history of Fx 2.4% Personal history of Fx 13.3% Body mass index  Underweight 1.2%  Normal 27.4%  Overweight 49.4%  Obese 22.0%  Height loss 42.4%  Calcium ≥800 mg 17.9%  Use of steroids 1.0%

Smoking  Current smoking 22.8%  Ever smokers 40.4%  Never smokers 36.8% Alcohol intake  Never 46.0%  1–10 gr/day 48.9%  10–40 gr/day 0.5%  >40 gr/day 4.6% Physical activity  ≥30 min/day 48.2% Table 3 Risk factors for vertebral fracture in Mexican men Variablea N 413b % Bivariate OR (IC 95%) p value Multivariate OR (IC 95%) p value Maternal history HSP targets of fractures  No 39/403 9.7 1   1  

 Yes 1/10 10.0 1.04 (0.02–7.84) 0.97 1.37 (0.15–12.64) 0.77 History of fracture  No 32/358 8.9 1   1    Yes 8/55 14.5 1.73 (0.69–4.23) 0.28 1.57 (0.612–4.03) 0.34 Body mass index  Underweight 0/5 0          Normal 12/113 10.6 1   1    Overweight 19/204 9.3 0.86 (0.38–1.98) 0.85 1.09 (0.47–2.50) 0.82  Obese 9/91 9.9 0.92 (0.34–2.50) 0.95 Selonsertib price 1.65 (0.59–4.58) 0.33 Height loss  No 11/198 5.6 1   1    Yes 26/175 14.9 2.97 (1.35–6.63) 0.068 2.08 (0.94–4.61) 0.06 Calcium dietary <800 mgs 34/339 10.0 1   1   ≥800 mgs 6/74 8.1 1.26 (0.48–3.50) 0.77 0.66 (0.25–1.74) 0.40 Smoking  Never 12/152 7.9 1   1    Ever 19/167 11.4 1.50 (0.66–3.42) 0.37 1.45 (0.64–3.29) 0.37  Current 9/94 9.6 1.24 (0.46–3.13) 0.37 Flavopiridol (Alvocidib) 1.56 (0.58–4.21) 0.37 Alcohol intake gr/d  Never 23/190 12.1 1   1    1–10 16/202 7.9 0.67 (0.30–1.28) 0.44 0.74 (0.35–1.58) 0.40  11–40 0/2 0          >40 1/19 5.3 0.40 (0.01–2.82) 0.48 0.46

(0.05–3.89) 0.48 Physical activity  0–29 min/day 16/117 13.7 1   1    ≥30 min/day 13/199 6.5 0.49 (0.21–1.20) 0.19 0.56 (0.24–1.32) 0.19 aMultivariable analysis adjusted by age bNumber of positive observations/total observations for each https://www.selleckchem.com/mTOR.html factor Discussion This is the first study that reports the prevalence of vertebral fractures in Mexican men in which there was an overall prevalence of 9.7% (95% CI 6.85–12.55). The prevalence of vertebral fractures in men is half the prevalence estimated for women (19.2% 95% CI 15.3–33.0) recently published in the LAVOS study using the same methodology [6]. The presence of vertebral fractures rises with age from 2.0% in the youngest group (50–59 years) to 21.4% in the oldest group (80 years and over). This same pattern were found in Mexican women with steady age increments, but the higher prevalence in women starts at age 70, whereas in men, the higher prevalence starts a decade later (80 and over).