There is again no mention of non-migraine headaches. Eight treatment subjects experienced no significant change (12%). The subjects who proceeded with surgery experienced multiple complications that were present at 5-year follow-up. These complications included 20 subjects with occasional itching, 3 subjects had hair thinning at the surgical site, 2 subjects had hypersensitivity (frontal),

2 subjects had hyposensitivity (frontal), 2 subjects had numbness (frontal), and 3 subjects had mild occipital stiffness or weakness. One subject had facial nerve injury with complete recovery. The author specifically notes that no subjects had persistent intense itching Gemcitabine at 5 years, which leaves the possibility that some degree of itching at the surgical site may have been present. The authors report that among the 69 subjects in the final analysis, 61 had improvement of their headaches at the 5-year follow-up evaluation.

The author then comments that a placebo effect is highly unlikely in these subjects that have been followed OTX015 clinical trial over 5 years. It is then noted that in other studies, a positive response rate (reduction by 50%) of over 90% and a migraine elimination rate of over 70% is noted throughout the literature. The author then remarks that better detection and deactivation of trigger sites, as well as improving surgical techniques, may improve these success rates. The author specifically notes that resection of the temporal artery can be considered

in cases involving the auriculotemporal branch of the trigeminal nerve. Regarding the lesser occipital nerve, the author advocates neurectomy and “burying the tied end of the nerve in the adjacent muscle” followed by triamcinolone injection to avoid neuroma formation. These additional surgical techniques are based on little evidence. Commentary is then made about Acetophenone rebound headache, and subjects taking opiates, which is the only time the author comments on medications that are taken during the study. It is not surprising that the only medications noted by the author are those that may negatively impact study results (medication overuse headache), as there is no mention of preventative and abortive medications that can positively impact statistical analysis. The author once again lumps together these 4 procedures, and uses this collective weak data to reinforce these self-promoting curative surgical interventions. The improvement of a patient’s pain with nerve blocks or BTX could be used to persuade a patient to proceed with an expensive surgical treatment with unclear benefit and potentially irreversible complications including worsening of pain.