This may be followed by maintenance [52]. Specific immunotherapy has also been used as treatment for MCD. Interferon-alpha (IFN-α) has been administered either alone or in combination with cART or chemotherapy for patients with MCD both to induce remission and as maintenance therapy [51,53,54]. IFN-α used in combination with vinblastine and splenectomy contributed to the long-term remission of two of three patients [51]. In a case report a patient was initially treated with antiviral therapy and splenectomy followed by chemotherapy to induce remission and, after relapse, IFN-α therapy

[54] led to remission for over a year. A further case report of treatment of www.selleckchem.com/products/Roscovitine.html MCD with cART and low-dose IFN-α alone has shown a sustained remission of 24 months [55]. The case for steroid treatment, other than as an adjunct for chemotherapy regimens is unproven, although many practitioners advocate their use to prevent or lessen the effects of a cytokine ‘storm’. As the pathogenesis of MCD is related to HHV8 virus and its viral Dabrafenib research buy oncogenes, particularly vIL-6, monoclonal anti-IL-6 therapy has also been used in the treatment of MCD. Seven HIV-negative

patients were treated with atlizumab, a humanized monoclonal anti-IL-6 receptor antibody in patients with either multicentric plasma cell or mixed variant Castleman’s disease. They had resolution of their immediate symptoms and, by 3 months, all had reduction in lymphadenopathy and hypergammaglobulinaemia with improvement of renal function, the result of secondary amyloidosis. This remission was not sustained [56]. These studies have been expanded to a multicentre clinical trial in Japan [57] but there are no reports of the use of atlizumab in persons with HIV. In below an ongoing Phase I study, neutralization of IL-6 activity by siltuximab has led to a high objective tumour response

rate (52%) and clinical benefit rate (78%) in subjects with MCD with a favourable safety profile. These results have prompted a trial to definitely assess the efficacy and safety of siltuximab in combination with best supportive care (BSC) versus placebo + BSC which has not yet been published [58]. Recent case reports of treatment with thalidomide also showed resolution of systemic manifestations of MCD, and the patients included one with HIV [59,60]. Thalidomide is known to have a powerful anticytokine effect and inhibits tumour necrosis factor and other pro-inflammatory cytokines. As MCD has been shown to be a virally driven disease, with the presence of viral genes such as vIL-6 having an effect on pathogenesis, the effect of anti-herpesvirus therapy to reduce the KSHV viral load and alleviate disease has been examined in HHV8-associated diseases in the HIV setting.