Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women.”
“Poly (L-lactic acid) (PLA) is a biodegradable polymer with slow crystallization rate. Oligomers of 3-hydroxybutyrate (OHB) and dendrimers of hydroxyalkanoic acids with different molecular weights were blended with PLA in a hope to improve the crystallization Volasertib inhibitor ability

and thermal stability of PLA, respectively. Four thermally-degraded PHB products oligomers termed OHB-1, OHB-2, OHB-3, and OHB-4 with various number average molecular weights (M(n)) of 4000, 7400, 14,000, and 83,000, respectively, were blended with PLA. The lower cold-crystallization temperature (T(cc)) and higher heat of cold crystallization (Delta H(cc)) for blend of PLA/OHB-1

suggested that thermally-degraded OHB-1 formed suitable crystal size during the cooling process and then acted as nucleation agents for PLA in the subsequent heating process. On the other hand, for the blending systems of PLA/dendrimers of hydroxyalkanoic acids, no obvious change on the thermal properties was observed compared with pure PLA except an improved PLA thermal stability possibly resulted from the crosslinking effects of the Captisol cell line dendrimers (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 1720-1727, 2009″
“BACKGROUND

This study involved model

evaluation of the acute impact of sulfamethoxazole on utilization of peptone mixture find more and acetate by fast growing microbial cultures under aerobic conditions. These substrates were selected to represent complex and readily biodegradable organic carbon sources, respectively. Acclimated biomass was obtained from two fill/draw reactors sustained at a sludge age of 2 days, one fed with peptone mixture and the other with acetate. Acute inhibition was tested in two parallel sets of batch reactors. Each reactor set was started with acclimated biomass seeding and pulse sulfamethoxazole dosing, including a control reactor without antibiotic addition.

RESULTS

Model evaluation of the oxygen uptake rate, chemical oxygen demand and intracellular storage profiles indicated that sulfamethoxazole stopped substrate storage and accelerated endogenous respiration, but it did not affect microbial growth. The major inhibitory effect was on process stoichiometry, leading to partial substrate utilization. Enhanced endogenous respiration could be explained by higher maintenance energy required for possibly generating specific resistance mechanisms against the inhibitory effects of sulfamethoxazole.

CONCLUSION

The impact of sulfamethoxazole was different depending upon the nature of the substrate. For peptone mixture, it was stoichiometric, leading to partial substrate utilization.