Under the microscope, only insignificant remnants of white matter can Lonafarnib be seen within this zone. The stroke of the occipital lobe therefore caused a degeneration of the entire stratum sagittale externum in the

temporal lobe. A marked contrast is the cingulum in the gyrus hippocampi, which usually joins the stratum sagittale externum and is now stained deep black.Plate 1, Plate 2, Plate 3 and Plate 4 Burdach, 1826, Sachs, 1893, Sachs, 1905, Sachs, 1909. “
“Conceptual knowledge for objects comprises a diverse set of information about their sensory qualities, motor plans and verbal associations. How are these disparate sources of information linked to form a concept? According to one influential view, originally proposed by Wernicke (Wernicke, 1900; as cited in Eggert, 1977), conceptual knowledge for objects arises from the co-activation of their sensory-motor properties within a network of modality-specific

processing regions that are widely distributed throughout the cortex (Barsalou, 2008, Martin, 2007 and Pulvermuller, 2001). This approach makes two key predictions concerning the breakdown of conceptual knowledge under brain damage. First, damage to a single, modality-specific region should give rise to knowledge deficits that disproportionately affect properties in that find more modality and, by extension, categories of objects for which the affected modality is particularly central (Capitani et al., 2003, Mahon and Caramazza, 2009 and Warrington and Shallice, 1984). So, for example, damage to regions of inferior parietal cortex involved in representing skilled actions should impair knowledge of how objects are manipulated and lead to a disproportionate deficit for tools (Buxbaum & Saffran, 2002). The second prediction concerns global, pan-modal conceptual

impairments. According to Wernicke and his modern counterparts, these should only occur as a result of global cortical damage, because only damage to all of the modality-specific regions would be sufficient to produce a global impairment. This prediction is challenged by DOK2 the neurodegenerative syndrome of semantic dementia (SD). SD patients suffer from a global conceptual knowledge deficit that affects all categories of object and word (Hoffman and Lambon Ralph, 2011 and Lambon Ralph et al., 2007) and all sensory-motor modalities (Bozeat et al., 2000, Bozeat et al., 2002, Luzzi et al., 2007 and Piwnica-Worms et al., 2010), yet the cerebral atrophy and hypometabolism that gives rise to this debilitating impairment is not global: it is focused bilaterally on the anterior ventrolateral and polar portions of the temporal lobes (Galton et al., 2001 and Mion et al., 2010). Evidence from functional neuroimaging (Binney et al., 2010 and Visser and Lambon Ralph, 2011) and transcranial magnetic stimulation (Pobric et al., 2007 and Pobric et al.