89 (95% CI 0.50–1.60) and with dosulepin 0.83 (95% CI 0.46–1.52). In addition, no evidence was found that venlafaxine use was associated with a higher risk of out-of-hospital haemodynamically significant acute ventricular tachyarrhythmia compared with the other antidepressants. It was therefore concluded that venlafaxine was not associated with an excess risk of cardiac death or near death compared with fluoxetine, citalopram or dosulepin in patients with Inhibitors,research,lifescience,medical depression or anxiety. A nationwide study performed in Denmark examining the association of antidepressant use and out-of-hospital cardiac arrest (OHCA) has recently been published [Weeke et al. 2012]. All patients in Denmark who experienced an OHCA between 2001

and 2007 were identified (19,110 in total) Inhibitors,research,lifescience,medical and associations between specific antidepressants and OHCA examined with conditional logistic regression in case–time–control models. A total of 2913 patients were receiving antidepressants at the time of the OHCA. TCAs (OR 1.69, 95% CI 1.14–2.50) and SSRIs (OR 1.21, 95% CI 1.00–1.47) were both associated

with comparable increases in risk of OHCA. No association Inhibitors,research,lifescience,medical was found for SNRIs/noradrenergic and specific serotonergic antidepressants (NaSSAs) (OR 1.06, 95%CI 0.81–1.39). Citalopram (OR 1.29, 95%CI 1.02–1.63) and nortriptyline (OR 5.14, 95% CI 2.17–12.2) had the strongest associations. Venlafaxine had the lowest OR of 0.68 (95% CI 0.38–1.22) from 177 identified cases of OHCA and hence no evidence was found that venlafaxine increased the risk of OHCA. A review of 37 patients with depression taking high therapeutic doses of venlafaxine Inhibitors,research,lifescience,medical (mean dose 346.15 mg/day) did not reveal any clinically significant change in QTc intervals [Mbaya et al. 2007]. However, there is a case report of significant QTc prolongation associated with venlafaxine 150 mg/day in an older lady with depression who had a QTc interval of 582 ms which reduced to 430 ms several days after discontinuing venlafaxine [Letsas et al. 2006]. Other cardiovascular-related adverse events Another area of potential concern for SNRIs is well recognized and relates to the potential to

Inhibitors,research,lifescience,medical increase pulse and blood pressure because of inhibition of reuptake of noradrenaline. These are covered under the SPCs for duloxetine and venlafaxine (both available from http://www.emc.medicines.org.uk). The SPC Histone demethylase for duloxetine gives a warning that blood pressure monitoring is recommended in patients with known hypertension or other cardiac disease. It also states that duloxetine should be used with caution in patients whose conditions could be compromised by an increase in heart rate or blood pressure. The SPC for venlafaxine (Efexor XL, check details Pfizer Ireland Pharmaceuticals, County Kildare, Republic of Ireland) is slightly different in that it recommends all patients should be screened for hypertension prior to initiation and all patients should have their blood pressure monitored.