[F-18]FLT appears promising for monitoring chemosensitivity in breast cancer. (c) 2009 Elsevier Inc. All rights reserved.”
“Objectives: The study defined the selection criteria used for treatment of ruptured abdominal aortic aneurysms (RAAAs) and
reviewed results during a 5-year period.
Methods: From 2002 on, our tertiary referral center adopted a protocol of selective use of endovascular repair LEE011 chemical structure for RAAAs. The study included all patients with a proven RAAA who were admitted to our hospital from 2002 to 2006. The primary Outcome measure was surgical mortality.
Results: A total of 187 patients were admitted with an acute AAA, and an RAAA was confirmed 135 (72%) by computed tomography scanning or at laparotomy, and 125 (93%) were treated, 89 by open means and 36 by endovascular means. The overall mortality rate was 24% and the mortality rate was 13.9% for endovascular repair. Endovascular repair was consistently used more often in patients with
favorable anatomy and in patients who were hemodynamically more stable. There were considerable differences in approach between the four consultant vascular surgeons. The overall evaluation and inclusion for endovascular treatment increased during the study period.
Conclusions. A strict protocol for admission, evaluation, and treatment of RAAA, with Selinexor ic50 selective use of endovascular repair, resulted in low mortality rates in our center. (J Vasc Surg 2008;48:1396-1400.)”
“Introduction: Human breast cancer, front which the T-47D cell line was derived, is known to overexpress the gastrin-releasing peptide receptor (GRPR) in some cases. Bombesin (BBN), in agonist for the GRPR. has been appended with a radionuclide capable of positron-64 emission tomography (PET) imaging and therapy. Cu-64-NO2A-8-Aoc-BBN(7-14)NH2 (NO2A=1,4,7-triazacyclononane-1,4-diacetate) has produced high-quality microPET images of learn more GRPR-positive breast cancer xenografted tumors in Mice.
Methods:
The imaging probe was synthesized by solid-phase peptide synthesis followed by manual conjugation of the 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) bifunctional chelator and radiolabeling in aqueous solution. The radiolabeled conjugate was subjected to in vitro and in vivo studies to determine its specificity for the GRPR and its pharmacokinetic profile. A T-47D tumor-bearing mouse was imaged with microPET/CT and microMRI imaging.
Results: The Cu-64-NO2A-8-Aoc-BBN(7-14)NH2 targeting vector was determined to specifically localize in GRPR-positive tissue. Accumulation was observed in the tumor in sufficient quantities to allow for identification of tumors in microPET imaging procedures. For example, uptake and retention in T-47D xenografts at 1, 4 and 24 h were determined to be 2.27 +/- 0.08, 1.35 +/- 0.14 and 0.28 +/- 0.07 % ID/g respectively.
Conclusions: The Cu-64-NO2A-8-Aoc-BBN(7-14)NH2 produced high-quality microPET images.