These cases were studied during

the 2010 dengue epidemic in Ribeirão Preto, when around 30,000 dengue cases were identified [DATASUS, 2011]. During dengue infection, these three refractory patients with schizophrenia were admitted to our psychiatric ward, where close clinical and laboratory monitoring Inhibitors,research,lifescience,medical was implemented. The patients presented different outcomes with regard to hematological alterations, with two of them requiring CLZ suspension due to neutropenia. We describe the successful rechallenge with CLZ subsequently implemented. Table 2. Data on the three patients described in this report. Results Patient A A 23-year-old white man, diagnosed with schizophrenia 6 years previously,

had been treated with CLZ as a refractory patient for 20 months without major complications. After 1 month of in-house sellectchem treatment using daily CLZ 500 mg and clomipramine 75 mg (to treat obsessive compulsive symptoms) and following considerable symptom improvement, the Inhibitors,research,lifescience,medical patient returned from a weekend discharge reporting 2 days of high fever, nausea, and bone and muscle pain. A physical exam revealed a body temperature (BT) of 38ºC, blood pressure (BP) of 110 × 70 mmHg, Inhibitors,research,lifescience,medical pulse rate (PR) of 90/min, no signs of dehydration and a maculopapular rash around his face and trunk. Complete blood count (CBC) during readmission showed a hematocrit (Hct) of 47%, WBC count of 1600 [absolute neutrophil count (ANC) 800 and leucocytes (L) 600], and a platelet (plt) count of 92,000. Dengue infection was Inhibitors,research,lifescience,medical suspected, and due to the symptoms,

CLZ was immediately discontinued. On the third day after readmission, a dengue rapid test [Immunoglobulin M (IgM)] came back positive. Clinical improvement with regard to hematologic normalization was apparent 3 days later. However, a critical worsening of the schizophrenic psychopathology was observed, with the patient in a catatonic state most of the time and muttering during some periods Inhibitors,research,lifescience,medical of the day. Because of the previous complete lack of response to a Drug_discovery wide variety of antipsychotics other than CLZ, before a reintroduction of any other medication, a course of electroconvulsive therapy was implemented. However, after eight sessions without improvement, the staff decided to try a rechallenge with CLZ, believing that the major cause of the hematologic alteration was the dengue infection. His WBC count had been normal during the past 50 days, so CLZ was carefully reintroduced until the previous dosage of 500 mg/day was reached after 2 months. Four months later, with that dosage of CLZ, along with sertraline 50 mg/day and lamotrigine 100 mg/day, the patient was discharged with an acceptable improvement in the psychopathology and without hematologic alterations.