(C) 2009 Elsevier Ireland Ltd All rights reserved”
“Oral Di

(C) 2009 Elsevier Ireland Ltd. All rights reserved”
“Oral Diseases (2012) 18, 786792 Objective: In the last two decades, the use of mobile phones has increased enormously all over the world.

The controversy regarding whether radiofrequency (RF) fields exert effects upon biological systems is a concern for the general population. An evaluation is made of DNA damage and cytokinetic defects, proliferative potential, and cell death because of RF radiation emitted by mobile phones in healthy young users. Study design: This cohort study was carried out in 50 Caucasian mobile phone users. We collected two cell samples from each subject (a total of 100 cell samples), corresponding to the right and left cheek mucosa, respectively. Case histories and personal information eFT-508 inhibitor were assessed, including age, gender,

body height and weight, history of cancer, smoking and alcohol consumption, exposure to chemical carcinogens or radiation, and dietary habits. Sampling comprised cell collection from both cheeks with a cytobrush, centrifugation, slide preparation, GKT137831 cost fixation, and staining, followed by fluorescent microscopic analysis. A total of 2000 exfoliated cells were screened for nuclear abnormalities, especially micronucleus. Results: No statistically significant changes were recorded in relation to age, gender, body mass index, or smoking status. A comparison of the results vs the control area according to the PCI-34051 mouse side of the face on which the mobile phone was placed, and in relation to the duration of exposure (years) to mobile phone radiation in the total 100 samples, yielded no significant differences. Conclusions: No genotoxic effects because of RF exposure were observed in relation to any of the study parameters.”
“Background: Slow heart rate recovery (HRR) after exercise is considered to represent impaired parasympathetic tone and to be a predictor of all-cause and cardiovascular mortality, but the independent value of abnormal

HRR in predicting the presence and severity of coronary artery disease (CAD) is unknown. The aim of this study was to evaluate these relationships in our patients.\n\nMethods: This prospective cross-sectional study included 208 patients (67.3% men), aged 34 to 74 (mean 53) years. Patients who had an ischemic response during symptom-limited exercise testing underwent selective coronary angiography. The value for HRR was defined as the decrease in heart rate from peak exercise to one minute after the exercise ceased. Eighteen beats per minute was defined as the lowest normal value for HRR.\n\nResults: Significant CAD was detected in 140 (67.3%) patients. There were 66 (31.7%) patients with an abnormal HRR.

The composite ceramics with 50 wt % PLZST content

The composite ceramics with 50 wt % PLZST content check details possess a considerable FE-to-AFE phase transition electric field of 130 kV/cm and a high saturation polarization of 49.8 uC/cm(2) at room temperature. As a result, the maximum value of energy storage density is obtained to be 4.65 J/cm(3). (C) 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.”
“Exposure to natural disasters has been linked to a range of adverse outcomes, including mental health problems (e.g., posttraumatic stress symptoms [PTSS], depression), declines in role functioning (e.g., occupational difficulties), and physical health problems (e.g., somatic complaints). However, prior research and theory suggest that the

modal postdisaster response in each of these domains is resilience, defined as low levels of symptoms or problems in a given outcome over time, with minimal elevations that are limited to the time period during the disaster and its immediate aftermath. However, the extent to which disaster survivors exhibit mental health wellness (resilience across multiple mental health conditions) or general wellness (resilience across mental health, physical health, and role functioning domains)

remains unexplored. The purpose of this study was to quantify mental health and general wellness, and to examine predictors of each form of wellness, in a three-wave Selleck GSK2126458 population-based study of Hurricane Ike survivors (N = 658). Latent class growth analysis was used to determine the frequency of resilience on four outcomes (PTSS: 74.9%; depression: 57.9%; functional

impairment: 45.1%; days of poor health: 52.6%), and cross-tabulations were used to determine the frequency of mental health wellness (51.2%) and general wellness (26.1%). Significant predictors of both mental health and general wellness included lower pen-event emotional reactions and higher community-level collective efficacy; loss of sentimental possessions or pets and disaster-related financial loss were negative predictors of mental health wellness, and loss of personal property was a negative predictor of general wellness. The results suggest that studies focusing on a single postdisaster outcome may have overestimated the prevalence of mental health and general Selleckchem Go6983 wellness, and that pen-event responses, personal property loss and collective efficacy have a cross-cutting influence across multiple domains of postdisaster functioning. (C) 2014 Elsevier Ltd. All rights reserved.”
“Pre-pregnancy overweight and obesity is associated with shorter breastfeeding (BF) duration. Whether pre-pregnancy overweight and obesity is associated with other aspects of infant and young child feeding (IYCF) has not been investigated. We used data from 370 children born January 1999-September 2001 in a semi-urban community in Morelos, Mexico, where information on how they were fed was available at 1, 3, 6, 9, 12, 18 and 24 months of age.

Conclusions CD133 may play an important role in chemoresistance a

Conclusions CD133 may play an important role in chemoresistance and recurrence, thus representing a promising predictive marker for the prognosis of gastric cancer. J. Surg. Oncol. 2012; 106: 9991004. (c) 2012 Wiley Periodicals, Inc.”
“Aims: To

compare the existing model estimates of the appropriate rates of https://www.selleckchem.com/products/nct-501.html radiotherapy for lung, breast and prostate cancers with actual radiotherapy rates in rural, semi-urban and urban areas, and in areas with short and long drive distances to cancer clinics in British Columbia.\n\nMaterials and methods: : All registered cases of lung, breast and prostate cancer diagnosed in British Columbia between 1997 and 2007 were identified. The proportion of cancers treated within 1 (RT(1y)) and 5 years (RT(5y)) of diagnosis were calculated according to rural, semi-urban and urban area, and areas associated with short and long drive distances to cancer clinics in British Columbia.\n\nResults: RT(1y) for lung, breast and prostate in urban this website and rural areas were 47/45%, 57/46% and 31/30%, and for short and long drive times were 47/44%, 56/50% and 31/31% compared with model estimates for initial radiotherapy needs of 41-45%, 57-61% and 32-37%, respectively. RT5y for lung, breast and prostate in urban and rural areas were 52/47%, 59/48% and 42/39%, and for short and long drive times were 51/47%, 57/50% and 42/42% compared with model estimates for overall radiotherapy needs of

66-83%, 57-61% and 60-61%, respectively.\n\nConclusions: Radiotherapy rates vary between and within urban and rural areas in British Columbia. Radiotherapy rates for breast and lung cancer patients are higher, and closer to model estimates see more of need, in urban areas and short drive time areas. Radiotherapy rates do not vary with drive time or rural versus urban classification for patients with prostate cancer. (C) 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.”
“Background/Aims: The association between clinical symptoms and sleep disorders in functional dyspepsia (FD)-overlap syndrome has not been studied in detail.\n\nMethods: The subjects were

139 patients with FD, 14 with irritable bowel syndrome (IBS), 12 with nonerosive reflux disease (NERD), and 41 healthy volunteers. Gastric motility was evaluated with the C-13-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms, and Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Sleep disorders were evaluated with Pittsburgh Sleep Quality Index (PSQI) scores.\n\nResults: There were no significant differences in age, body-mass index, alcohol intake, and smoking rate between patients with FD alone and those with FD-overlap syndrome. The postprandial abdominal fullness score in patients with FD-NERD-IBS was significantly greater than that in patients with FD-NERD overlap syndrome (p<0.

Phormidium and Romeria) and (iii) Nostocales (Nostoc and Nodulari

Phormidium and Romeria) and (iii) Nostocales (Nostoc and Nodularia). 19 morphotypes were assigned at the species

level, while phylogeny allowed us to distinguish 21 phylotypes spread amongst three distinct large clades. McyA KU-55933 purchase and sxtl gene fragments were detected in some isolates, despite absence of toxins. Simultaneous presence of anabaenopeptins A and D was for the first time identified in Nostoc (LEGE06077). No correlation between morphological/phylogenetic relationships and the secondary-metabolite profile of the isolates was found. This is the first comprehensive study of estuarine cyanobacteria of Portuguese habitats revealing a diverse array of cyanobacteria that constitute an important source of potential bioactive compounds with ecological relevance and/or biomedical application. (C) 2011 Elsevier Ltd. All rights reserved.”
“We performed a total gastrectomy in a 16-year-old asymptomatic CDH1 gene mutation carrier in whom two prior gastroscopies with biopsies

were normal. The patient’s mother died aged 39 years and her aunt died aged 21 years of gastric cancer. A germline CDH1 mutation (associated with hereditary diffuse gastric cancer) was initially identified in her mother at diagnosis and was later identified by predictive testing in this patient. Our patient is the youngest CDH1 carrier to date to have a prophylactic gastrectomy, and is several years below the age at which existing guidelines recommend consideration CH5183284 order Selleck NCT-501 of gastrectomy. Multiple foci of early-stage carcinoma were found in her gastrectomy

specimen. Given the family history of advanced gastric cancer in the late second decade, the unpredictable time course to development of advanced gastric cancer, and the futility of gastroscopic surveillance, we recommend consideration of prophylactic gastrectomy in adolescent asymptomatic CDH1 mutation carriers on an individual basis.”
“Here, we described a simple approach for the development of advanced composites based on Nylon 12 by selectively modified multiwalled carbon nanotubes (MWCNTs). Prior mixing, MWCNTs were modified by a new combination of plasma treatment i.e. oxygen + nitrogen (PL-MWCNTs) in order to improve its dispersion in the nylon matrix and enhance the interfacial adhesion by increasing the compatibility. With incorporation of only 1.2 wt % PL-MWCNTs, the tensile strength, Young’s modulus, elongation at break and storage modulus of Nylon 12 were dramatically improved by similar to 66%, 64%, 69% and 39%, respectively. These results were found to be higher than individual plasma treated CNTs. Such large increments were due to the effects of excellent homogeneous dispersion of PL-MWCNTs in the Nylon matrix and strong interfacial adhesion within themselves, which is believed to be effects of both oxygenated and nitrogenated functional groups generated on the surface of CNTs during plasma treatment. (C) 2014 Elsevier Ltd. All rights reserved.

The principal positivity of cases, the site of signal presence an

The principal positivity of cases, the site of signal presence and the quantitative parameters concerning selleck chemicals percentage of positive cells and labelling intensity were determined. Acinic cell and adenoid cystic carcinomas (specifically tubular and cribriform types) shared the expression signature of Gal-1, Gal-3 and Gal-8 presence combined with Gal-7 absence. Mucoepidermoid carcinomas presented a unique profile based on cytoplasmic Gal-1, Gal-3, Gal-7 and Gal-8 localization in the intermediate cells. Adenomas were separable from malignancy

by a consistent decrease in the labelling index (LI) for Gal-7 and Gal-8 (LI Gal-7, P < 10-6; LI Gal-8, P = 0.001). When present, staining for the tumour suppressor p16INK4a coincided with Gal-1 presence.\n\nConclusions:\n\nExpression profiling of the four tested galectins in salivary gland tumours revealed non-uniform 10058-F4 supplier staining patterns with discriminatory potential based on intracellular localization and quantitative aspects.”
“Young (6-8 years) and old (21-30 years) Macaca mulatta females were subjected to gentle immobilization (2 h daily at 15.00) for 10 days. Blood specimens were collected before the exposure and 15, 30, 60, 120, 240 min

and 24 h after the beginning of exposure on days 1, 3, and 10. The adrenocortical reaction to stress was maximum on day 1 in all animals. The increase of cortisol (F) and dehydroepiandrosterone sulfate (DHEAS) concentrations

in young monkeys decreased on days 3 and 10, DHEAS drop being less pronounced in comparison with F, as a result of which F/DHEAS molar concentration ratio changed negligibly. In old monkeys the basal DHEAS levels were lower, while the F/DHEAS ratio was higher than in young animals. Repeated immobilizations inhibited F elevation on day 3, caused no changes in DHEAS reaction, led to increase of basal DHEAS levels and to a reduction of F/DHEAS ratio on days 2, 3, 4, 10, 11. Hence, chronic moderate stress stimulated the production of DHEAS and reduced the corticosteroid imba lance in old monkeys.”
“Current Brain Trauma Foundation guidelines recommend avoiding hypoxemia after severe pediatric traumatic brain injury (TBI). Yet, recent studies on Selleck URMC-099 optimum admission oxygenation and ventilation parameters associated with discharge survival in pediatric TBI are lacking.\n\nAfter IRB approval, a retrospective study involving pediatric patients ages a parts per thousand currency sign14 years with severe TBI (head Abbreviated Injury Scale (AIS) score of a parts per thousand yen3, Glasgow Coma Scale score of a parts per thousand currency sign8 on admission) admitted to Harborview Medical Center (level 1 pediatric trauma center), Seattle, WA, during 2003 to 2007 was performed.

After obtaining baseline flare values, we randomly assigned one e

After obtaining baseline flare values, we randomly assigned one eye to BAK-preserved timolol and the fellow eye to preservative-free timolol. After 1 month, 17DMAG mw flare measurements were repeated. Results: There was a significant

increase in the flare values in the two treatment regimens, but the increase in the BAK-treated eyes was higher than in the preservative-free treated eyes, and this difference in increase was statistically significant. Conclusion: This is the first study to show that short-term BAK administration produces inflammation in the anterior segment of previously untreated patients whose bloodaqueous barrier was not affected by recent intraocular surgery.”
“Objective: The aim of this study was to establish a correlation between the diagnosis of ocular sarcoidosis and the presence of an elevated CD4/CD8 ratio in the induced sputum(IS) of patients with uveitis and no other systemic symptoms. Methods: This retrospective chart review study included all newly diagnosed uveitis patients treated between 1998-2006. IS examinations and determination of angiotensin-converting enzyme (ACE) levels were carried out. A CD4/CD8 ratio >2.5 and an ACE level >145 mu l/ml/min were considered abnormal. The etiology of uveitis was retrieved from the medical records. Results: Twenty males

and 26 females (mean age 47 +/- 16.1 years) were enrolled. The CD4/CD8 ratio was elevated in 26 (56.5%) patients, and five (10.9%) were diagnosed as having sarcoidosis by the end of follow-up. Cell Cycle inhibitor The sensitivity Cediranib inhibitor and specificity of the T lymphocytes CD4/CD8 ratio in diagnosing sarcoidosis were 100% and 48.8%, respectively. CD4/CD8 ratios were not significantly different between the sarcoid and non-sarcoid groups (p>0.05), but the former tended to have higher levels (p=0.0991).

The mean ACE level of the sarcoid patients was significantly higher than that of the non-sarcoid patients (p<0.001). Conclusion: CD4/CD8 lymphocytes ratios obtained by IS were sensitive in uveitis patients with concomitant sarcoidosis, suggesting that analysis of T cells subsets in IS may rule out an etiology of sarcoidosis in newly diagnosed uveitis patients.”
“P>Aim.\n\nThis paper is a report of an investigation of the relationship between health-related quality of life and left ventricular function among patients with hypertension who did not fulfil the criteria for heart failure.\n\nBackground.\n\nHeart failure is a common consequence of hypertension, with Doppler echocardiography being the gold-standard tool to evaluate left ventricular function, mainly hypertension-induced left ventricular damage. Echocardiographic data indicating poorer ventricular function have been related to lower levels of health-related quality of life in patients with systolic and/or diastolic heart failure.

For reasonable initial conditions, 2D simulations of our model ro

For reasonable initial conditions, 2D simulations of our model robustly generate spatially and temporally regular

somites, realistic dynamic morphologies and spontaneous emergence of anterior-traveling find more stripes of Lfng. We show that these traveling stripes are pseudo-waves rather than true propagating waves. Our model is flexible enough to generate interspecies-like variation in somite size in response to changes in the PSM growth rate and segmentation-clock period, and in the number and width of Lfng stripes in response to changes in the PSM growth rate, segmentation-clock period and PSM length.”
“BACKGROUND: Early detection of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) is of primary importance for both patient management and infection control. Optimal

methods for identifying MDR-TB in a timely and affordable manner in resource-limited settings are not yet available.\n\nOBJECTIVES: To evaluate the performance of a low-technology but rapid BKM120 drug susceptibility testing method, the microscopic observation drug susceptibility assay (MODS), in the concurrent detection of M. tuberculosis and its susceptibility to isoniazid (INH) and rifampin (RMP) directly from sputum specimens.\n\nMETHODS: A total of 115 smear-positive TB patients admitted to Abbasia Chest Hospital, Cairo, Egypt, were simultaneously tested using MODS and the BACTEC (TM) MGIT (TM) 960 mycobacterial detection system for the detection of M. tuberculosis and the identification of MDR-TB samples.\n\nRESULTS: MODS detected 112 (97.4%) samples and BACTEC MGIT detected 115 (100%). Of the 115 isolates tested for susceptibility to INH, RMP and MDR-TB, complete agreement between MODS and MGIT results was found among respectively 92.9%, 95.5% and 97.3% of samples. The sensitivity, specificity, and positive

and negative predictive values of MODS in the detection of MDR-TB were respectively 95.3%, 98.6%, Rapamycin 97.6% and 97.1%. MODS results were obtained in a median of 8 days (range 5-21).\n\nCONCLUSION: MODS is an optimal alternative method for timely and affordable identification of MDR-TB in resource-limited settings.”
“Background: dementia is one of the main challenges to our health and social care. This study compares the number and timing of transitions between care settings in the last 2 years of life among older people with and without dementia.\n\nMethods: data were derived from Finnish national registers, and include all those who died in 2002 and 2003 at the age of 70 or older (n = 70,366). Negative binomial regression analyses were used to analyse the impact of dementia on number of transitions among people with and without dementia and to adjust the number for age, gender and other diagnoses.

“This study presents a novel soft computing procedure base

“This study presents a novel soft computing procedure based on the application of artificial neural networks, genetic algorithms and identification systems, which

makes it possible to optimise the implementation conditions in the manufacturing process of high precision parts, including finishing precision, while saving both time and financial costs and/or energy. This novel intelligent procedure Selleck SNX-5422 is based on the following phases. Firstly, a neural model extracts the internal structure and the relevant features of the data set representing the system. Secondly, the dynamic system performance of different variables is specifically modelled using a supervised neural model and identification techniques.

This constitutes the model for the fitness function of the production process, using relevant features of the data set. Finally, a genetic algorithm is used to optimise the machine parameters from a non parametric fitness function. Selleckchem CP 868596 The proposed novel approach was tested under real dental milling processes using a high-precision machining centre with five axes, requiring high finishing precision of measures in micrometres with a large number of process factors to analyse. The results of the experiment, which validate the performance of the proposed approach, are presented in this study. (C) 2012 Elsevier B.V. All rights reserved.”
“Poison frogs in the genus Dendrobates (sensu Grant et al. 2006) are known to lay black pigmented eggs. During a field study in May 2010 in central Panama, a captive pair of wild-caught adult Dendrobates auratus laid a clutch of whitish eggs. The eggs developed and metamorphic froglets were similar in size GW786034 and color to that of age-matched normal-colored tadpoles produced by different parents and reared in exactly the same conditions. The observation of a pale pigmented tadpole in the wild suggests that polymorphism in the degree

of melanism is not simply an artifact of laboratory rearing. Our study is the first to report the production of viable whitish eggs by any species in the genus Dendrobates. Whether this coloration arises due to constraint or is a polymorphism that has adaptive significance awaits further study.”
“Aquaporin-1 (AQP1) facilitates the osmotic transport of water across the capillary endothelium, among other cell types, and thereby has a substantial role in ultrafiltration during peritoneal dialysis. At present, pharmacologic agents that enhance AQP1-mediated water transport, which would be expected to increase the efficiency of peritoneal dialysis, are not available. Here, we describe AqF026, an aquaporin agonist that is a chemical derivative of the arylsulfonamide compound furosemide. In the Xenopus laevis oocyte system, extracellular AqF026 potentiated the channel activity of human AQP1 by bigger than 20% but had no effect on channel activity of AQP4.

“Laromustine (VNP40101M, also known as Cloretazine) is a n

“Laromustine (VNP40101M, also known as Cloretazine) is a novel sulfonylhydrazine alkylating ( anticancer) agent. Laromustine generates two types of reactive intermediates: 90CE and methylisocyanate. When incubated

with rat, dog, monkey, and human liver microsomes, [(14)C]laromustine was converted to 90CE (C-8) and seven other radioactive components (C-1-C-7). There was little difference in the metabolite profile among the species examined, in part because the formation of most components (C-1-C-6 and 90CE) did not require NADPH but involved decomposition and/or hydrolysis. The exception was C-7, a hydroxylated metabolite, largely formed by CYP2B6 and CYP3A4/5. Laromustine BYL719 caused direct inhibition of CYP2B6 and CYP3A4/5 ( the two enzymes involved in C-7 formation) as well as of CYP2C19. K(i) values were 125 mu M for CYP2B6, 297 mu M for CYP3A4/5, and 349 mu M for CYP2C19 and were greater

than the average clinical plasma C(max) of laromustine ( 25 mu M). There was evidence of time-dependent inhibition of CYP1A2, CYP2B6, and CYP3A4/5. Treatment of primary cultures of human hepatocytes Sapitinib cost with up to 100 mu M laromustine did not induce CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP3A4/5, but the highest concentration of laromustine decreased the activity and levels of immunoreactive CYP3A4. The results of this study suggest the laromustine has 1) negligible victim potential with respect to metabolism by cytochrome P450 enzymes, 2) negligible enzyme-inducing potential, and 3) the potential in some cases to cause inhibition of CYP2B6, CYP3A4, and possibly CYP2C19 during and shortly after the duration of intravenous administration of this anticancer drug, but the clinical effects of such interactions are likely to be insignificant.”
“Aims To isolate, characterize and identify lactic acid bacteria (LAB) in yan-tsai-shin (fermented broccoli stems), a traditional fermented food in Taiwan. Methods and Results A total of 226 LAB were isolated; 111 cultures were isolated from samples collected from seven different markets and 115 from six fresh broccoli samples. These isolates were characterized phenotypically

and then initially divided into nine BB-94 price groups (r1 to r9) using restriction fragment length polymorphism analysis and sequencing of 16S ribosomal DNA. Some isolates were further divided into four additional groups by other genetic analysis. The most common bacterial genera in yan-tsai-shin and fresh broccoli were Weissella, Lactococcus and Lactobacillus. Regional similarities in the LAB, with differences in diversity, were observed in this study. On the basis of phylogenetic analysis of 16S rRNA, rpoA, rpoB and pheS gene sequences, two strains were included in the genera Enterococcus and Lactococcus, respectively, and identified as potential novel species or subspecies. In addition, the novel enterococcal strain, and 33 L.lactis subsp.

Methods Four cynomolgus monkeys were intravitreally injected with

Methods Four cynomolgus monkeys were intravitreally injected with 0.5 mg of ranibizumab and another four with 2 mg of aflibercept. Two untreated monkeys served as controls. Funduscopy, fluorescein angiography (FA), spectral-domain-optical coherence tomography (SD-OCT) and measurement of intraocular pressure (IOP) were performed. The eyes were inspected by light, fluorescence and electron microscopy. The diameter of the choriocapillaris (CC) was measured by morphometry, and the areas of the CC with free haemoglobin, CC fenestrations and endothelial thickness were quantified. Results Analysis showed ranibizumab permeated the

retina via intercellular clefts, whereas aflibercept was taken up by ganglion cells, cells of the inner and outer retinal layers and the retinal pigment epithelium (RPE). Stasis and haemolysis Selleckchem BEZ235 in the choriocapillaris and choroidal vessels were more frequent after aflibercept treatment, which caused hypertrophy and death of individual RPE cells. The area of the CC was significantly reduced after both drugs compared with controls, but the reduction of the CC endothelium thickness, number

of fenestrations and the areas with haemolysis were more pronounced after aflibercept. ATM/ATR mutation Conclusions Ranibizumab permeated the retina through intercellular spaces, whereas aflibercept was taken up by neuronal and RPE cells. Aflibercept induced protein complex formation and more haemolysis in the choriocapillaris, leading to individual RPE cell death. The clinical significance and relation of these findings to the Fc domain or to other characteristics of aflibercept remain to be investigated.”
“Objective. Knee and hip osteoarthritis (OA) are known risk factors for falls, but whether they together additionally contribute

to falls risk is unknown. This SNS-032 Cell Cycle inhibitor study utilizes a biracial cohort of men and women to examine the influence of lower-extremity OA burden on the risk for future falls. Methods. A longitudinal analysis was performed using data from 2 time points of a large cohort. The outcome of interest was falls at followup. Covariates included age, sex, race, body mass index, a history of prior falls, symptomatic OA of the hip and/or knee, a history of neurologic or pulmonary diseases, and current use of narcotic medications. Symptomatic OA was defined as patient-reported symptoms and radiographic evidence of OA in the same joint. Logistic regression analyses were used to determine associations between covariates and falls at followup. Results. The odds of falling increased with an increasing number of lower-extremity symptomatic OA joints: those with 1 joint had 53% higher odds, those with 2 joints had 74% higher odds, and those with 3-4 OA joints had 85% higher odds.